Marvel Biosciences Highlights Recent Research on Link Between NASH and Alzheimer's Disease

Calgary, Alberta--(Newsfile Corp. - August 31, 2022) - Marvel Biosciences Inc. (TSXV: MRVL) (the "Company" or "Marvel") highlights recent research indicating a link between non-alcoholic steatohepatitis (NASH) and Alzheimer's Disease (AD), two programs its lead asset, MB-204 are targeting.

A five-year longitudinal study in Sweden tracked subjects with and without NASH over the age of 65, and those with NASH had a 38% higher risk of developing dementia(1). With up to 25% of the population suffering with NASH, this could worsen the already alarming number of elderly patients with dementia which is estimated at more than 7 million diagnosed patients in the US alone(2).

"The link between NASH and AD is of concern, especially with an aging population," said Dr. Mark Williams, Chief Science Officer of Marvel. "Caffeine consumption appears to be protective in both diseases, and one of the key targets of caffeine is the adenosine A2a receptor. Our lead asset, MB-204, also targets the adenosine A2a receptor and has been shown in preclinical studies to improve NASH and depressive symptoms, the latter of which is common in Alzheimer's Disease patients as well."

"Currently there are no approved treatments for NASH, and very few effective treatment options for AD patients," said Rod Matheson, CEO of Marvel. "We are looking forward to advancing MB-204 to the clinic later this year with the hopes of being able to address both of these underserved conditions."

(1) Neurology (2022) 99:e574-e582

(2) https://www.prb.org/resources/fact-sheet-u-s-dementia-trends/

Contact Information

Investor Relations:
Virtus Advisory Group
Tel: 416-644-5081
Email: info@virtusadvisory.com

Marvel Biosciences Corp.
Roderick (Rod) Matheson, Chief Executive Officer or
Dr. Mark Williams, President and Chief Science Officer
Tel: 403 770 2469
Email: info@marvelbiosciences.com

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