Market Snapshot

CAGR:10.3
2020
2028

Source: Reports and data

RND-Favicon
Study Period 2018-2028
Base Year 2019
CAGR 10.3
Desalting and Buffer Exchange Market-companies
Desalting and Buffer Exchange Market-Snapshot

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Market Synopsis:

The global desalting and buffer exchange market size was USD 827.05 Million in 2020 and is expected to register a CAGR of 10.3% during the forecast period. Growing demand for monoclonal antibodies, rising investment and R&D expenditure by pharmaceutical and biotechnology firms, and increasing progress in proteomics and Genomics research are key factors expected to drive market revenue growth over the forecast period.

Increasing popularity and application of chromatography experiments in chemical sector and rapid advancements in the field of molecular chemistry are some other key factors expected to drive market revenue growth over the forecast period.

Desalting and buffer exchange are key methods applied to separate soluble large molecules from smaller molecules or exchange the buffer system used for a more suitable system for particular downstream applications. These methods are chiefly based on gel filtration chromatography, which is a major form of size exclusion chromatography. Desalting and buffer exchange both aim to recover components of a sample in buffers used to pre-equilibrate the small and porous polymer beads. Desalting is majorly carried out to remove salts from protein solutions, phenol from nucleic acids, or excess labeling reagents from conjugated proteins. Buffer exchange is carried to shift protein solution into a buffer system more suitable for downstream processes such as electrophoresis or affinity chromatography. Rapid advancements in the quality of materials and designs use to develop dialysis, diafiltration, and desalting devices to meet the growing demand for refined and convenient approaches needed by research laboratories are expected to contribute to revenue growth of the market over the forecast period. In addition, rapid progress of proteomics and genomics research are expected to further fuel revenue growth of the market going ahead.

Increasing R&D expenditure and investment in the biopharmaceutical sector across the globe is another key factor expected to drive market growth. Rising demand for monoclonal antibodies to develop more efficient therapeutic approaches to meet the unmet clinical demand is expected to further fuel revenue growth of the market. In addition, expiration of patents of crucial drugs and increasing opportunities for generic drugs in developing countries is expected to contribute to market growth over the forecast period. However, lack of knowledge about the methods, scarcity of skilled professionals, high costs associated with the techniques are expected to restrain market growth to a certain extent over the forecast period.

Market Dynamics:
Driver: Increasing demand for monoclonal antibodies is a key factor driving revenue growth

High specificity of monoclonal antibodies plays a significant role in therapeutic applications. The choice of source material can interfere with the choice of sample preparation and purification techniques due to differences in specific contaminants and quantity of target molecule required. Clarification of serum, culture supernatant, or cell lysates is an important step before chromatography procedure. Desalting and buffer exchange plays a crucial role in removing contaminants during sample preparation. Desalting columns are used for buffer exchange of any sample volume and many small contaminants are removed in a single step while simultaneously transferring the sample into appropriate buffer conditions. Desalting and buffer exchange are well-proven, simple, and fast methods that rapidly remove low molecular weight contaminants from antibodies and this is expected to boost their adoption in the laboratories and in preparation of monoclonal antibodies. This is expected to further drive revenue growth of the market over the forecast period. In addition, increasing research and development activities in the biopharmaceutical sector is expected to further drive revenue growth of the market over the forecast period.

Restraint: Lack of skilled professionals is a key factor restraining growth of the market

Desalting and buffer exchange methods requires precision and expertise to ensure purification of the sample results in high-quality sample devoid of all contaminants. Lack of skilled professionals and technicians is a limiting factor and this is expected to restrain market growth to a certain extent over the forecast period. In addition, high costs associated with reagents and equipment is also expected to hamper market growth to a certain extent over the forecast period. Furthermore, selecting a column size and format that is appropriate for the sample and a lot of optimization increases the time taken for the procedure and this can also affect the sample recovery percentage and this is expected to further restrain market growth to a certain extent over the forecast period.  

Product Outlook:

Based on product, the global desalting and buffer exchange market has been segmented into kit, cassette & cartridge, and spin columns. Kits segment is expected to register significant revenue growth over the forecast period owing to increasing demand and use of desalting kits in the preparation of analytical and concentrated protein samples. Increasing R&D expenditure and rising investment in biopharmaceutical sector by pharmaceutical and biotechnology companies is also a key factor expected to contribute to revenue growth of this segment over the forecast period.

Technique Outlook:

Based on technique, the global desalting and buffer exchange market has been segmented into chromatography, filtration, and precipitation. Chromatography is further segmented into size-exclusion chromatography and other techniques. Filtration is further segmented into ultrafiltration and dialysis techniques. Ultrafiltration is expected to contribute significantly to the revenue growth of the filtration segment over the forecast period. Growth can be attributed to growing demand for monoclonal antibodies. To achieve highly concentrated mAb solutions on a large scale, reliable and efficient ultrafiltration processes are required and this is expected to boost its adoption going ahead and drive revenue growth of this segment over the forecast period. In addition, increasing need to reduce production costs and numerous benefits offered by ultrafiltration techniques as compared to others is also key factors expected to contribute to revenue growth of this segment.  

Application Outlook:

Based on application, the global desalting and buffer exchange market has been segmented into bioprocess and diagnostic. Bioprocess segment is expected to register significant revenue growth over the forecast period. Growth can be attributed to increasing demand for monoclonal antibodies, fast-paced research and development in the field of bioprocessing, and increasing use of desalting kits for analytical sample preparation.

Regional Outlook:

Based on regional analysis, North America is expected to account for significant share in the market in terms of revenue over the forecast period, attributable to rising focus on genomics and proteomics research and increasing R&D activities and expenditure in biopharmaceutical sector. Growing demand and production of Biologics and robust presence of key companies are other factors expected to drive market revenue growth of the market in the region.

Asia Pacific market revenue is expected to expand considerably over the forecast period owing to rapid development of biotechnology sector in the region. Increasing penetration of clinical research organizations, growing biopharmaceutical sector, and availability of skilled professionals are some other key factors expected to contribute to revenue growth of the market in the region. Increasing research and development activities in the biotechnology sector and growing need for biologics are some key factors driving revenue growth of the market in Europe.

Competitive Landscape:

The global desalting and buffer exchange market is highly fragmented owing to high number of regional and global players. Key players are engaged in product development, strategic alliances, and expanding their product portfolio to cater to growing end-use demand and gaining a robust footing in the market. Major companies operating in the market include Thermo Fisher Scientific, Inc., Merck AG, GE Healthcare, Danaher Corporation, Sartorius, Agilent Technologies, Inc., VWR International LLC, Bio-works Technologies AB, Bio-Rad Laboratories, and Norgen Biotek Corp.

Some key developments in the market include:

  • In April 2020, Pall Corporation, which is one of the prominent leaders in filtration, separation, and purification, introduced the next-generation of the company’s lab-scale Tangential Flow Filtration (TFF) solutions, called the Minimate EVO TFF system. The system is easy to operate and is designed to simplify lab-scale concentration, desalting, and buffer exchange workflows.

Segments Covered in the Report:

This report offers historical data and forecasts revenue growth at a global, regional, and country level, and provides analysis of the market trends in each of the sub-segments from 2018 to 2028. For this study, Reports and Data has segmented the global desalting and buffer exchange market based on product, technique, application, and region:  

Commercial Vehicle Desalting and Buffer Exchange Market Report Scope

PARAMETERS DETAILS
The market size value in 2020 USD 827.05 Million
CAGR (2020 - 2028) 10.3%
The Revenue forecast in 2028

USD 1,691.9 Million 

Base year for estimation 2019
Historical data 2017-2018
Forecast period 2020-2028
Quantitative units
  • Revenue in USD Million

  • CAGR from 2020 to 2028

Report coverage Revenue forecast, company ranking, competitive landscape, growth factors, and trends
Segments covered By Product Outlook, Technique Outlook, Application Outlook, Regional Outlook
By Product Outlook 
  • Kits
  • Cassettes & Cartridges
  • Spin Columns
  • Others
By Technique Outlook
  • Filtration
    • Ultrafiltration
    • Dialysis
  • Chromatography
    • Size exclusion chromatography
    • Other chromatography techniques
  • Precipitation
By Application Outlook
  • Bioprocess Application
  • Diagnostic Application
Regional scope North America; Europe; Asia Pacific; Latin America ; Middle East & Africa
Country scope U.S.; Canada; U.K.; Germany; France; BENELUX; China; India; Japan; South Korea; Brazil; Saudi Arabia; UAE; Turkey
Key companies profiled Thermo Fisher Scientific, Inc., Merck AG, GE Healthcare, Danaher Corporation, Sartorius, Agilent Technologies, Inc., VWR International LLC, Bio-works Technologies AB, Bio-Rad Laboratories, and Norgen Biotek Corp.
Customization scope 10 hrs of free customization and expert consultation

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Key questions answered by the report