Our Studies
We conduct multiple research studies — the COVID Symptom Study, now known as the ZOE Health Study, and PREDICT, which is the largest in-depth nutrition study in the world, conducted with scientists from Massachusetts General Hospital, Stanford Medicine, Harvard T.H. Chan School of Public Health, and King’s College London.
Learn moreZOE PREDICT studies
STUDY OVERVIEW
We measured biological responses to specific foods in 1,106 people over 14 days, measuring blood glucose and fat levels, activity, inflammation, sleep and gut microbiome diversity. Our findings have been published in Nature Medicine in June 2020.
Participants: 1,106
Started: June 2018
Completed: September 2019
In partnership with researchers at:
STUDY OVERVIEW
An expanded home-based study that opened in June 2019. We recruited 1,200 volunteers across the US, measuring nutritional responses to food over a period of 11 days.
Participants: 1,200
Started: June 2019
Completed: March 2020
In partnership with researchers at:
STUDY OVERVIEW
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and individualized dietary advice.
Participants: 100,000
Started: July 2020
Completed: December 2023
In partnership with researchers at:
ZOE Health & Nutrition studies
World of Microbiome Conference
Keynote Lecture: Personalisation and the human microbiome
October 2023
EMBL Conference
Unraveling the complex interplay between the human gut microbiome, diet, and cardiometabolic health from the ZOE PREDICT studies. View PDF.
September 2023
BMC Medicine
Plasma protein N-glycome composition associates with postprandial lipaemic response
July 2023
Nutrients
Characterisation of fasting and postprandial NMR metabolites: Insights from the ZOE PREDICT 1 study
June 2023
Nature Medicine
Cardiometabolic health, diet and the gut microbiome: A meta-omics perspective
March 2023
Cell Reports Medicine
The secondary bile acid isoursodeoxycholate correlates with post-prandial lipemia, inflammation, and appetite and changes post-bariatric surgery
April 2023
Nature Biotechnology
Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4
February 2023
Nature Communications
How people wake up is associated with previous night’s sleep together with physical activity and food intake
November 2022
eBioMedicine
Menopause is associated with postprandial metabolism, metabolic health and lifestyle: The ZOE PREDICT study
November 2022
Nutrients
Postprandial responses to a standardised meal in hypertension: The mediatory role of visceral fat mass
October 2022
American Journal of Clinical Nutrition
Validity of continuous glucose monitoring for categorizing glycemic responses to diet and its potential for personalized nutrition
June 2022
Diabetology
Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions
February 2022
Nature Food
Diet and lifestyle behaviour disruption related to the pandemic was varied and bidirectional among US and UK adults participating in the ZOE COVID Study
16th December 2021
Gut
Diet quality and risk and severity of COVID-19: A prospective cohort study
6th September 2021
Journal of Hypertension
Gut microbiome diversity and composition is associated with hypertension in women
1st September 2021
American Journal of Clinical Nutrition
Meal-induced inflammation: Postprandial insights from the PREDICT study in 1,000 participants
8th June 2021
BMJ
Modest effects of dietary supplements during the COVID-19 pandemic: Insights from 445,850 users of the COVID-19 Symptom Study app
19th April 2021
Nature Metabolism
Postprandial glycemic dips predict appetite and caloric intake and are determined by meal content and insulin secretion in healthy individuals: the PREDICT 1 study.
12th April 2021
BMC Medicine
High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome
11th February 2021
Nature Medicine
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
11th January 2021
Nature Medicine
Human postprandial responses to food and potential for precision nutrition
11th June 2020
Gut
Blue poo: Impact of gut transit time on the gut microbiome using a novel marker
15th March 2020
Protocol Exchange
Personalised REsponses to DIetary Composition Trial (PREDICT): An intervention study to determine inter-individual differences in postprandial response to foods
14th January 2020
ZOE COVID Studies
The Lancet
Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2
18th June 2022
The Lancet
Risk of hospitalisation and death in children with SARS-CoV-2 delta (B.1.612.2) infection
29th March 2022
Nature Communications
Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom
1st February 2022
The Lancet eClinical Medicine
Disentangling post-vaccination symptoms from early COVID-19
1st December 2021
Scientific Data
Accessible data curation and analytics for international-scale citizen science datasets
22nd November 2021
The Journals of Gerontology: Series A
Individual factors including age, BMI, and heritable factors underlie temperature variation in sickness and in health: An observational, multi-cohort study
5th October 2021
Journal of Neurology, Neurosurgery and Psychiatry
Anxiety and depression symptoms after COVID-19 infection: Results from the COVID Symptom Study app
28th September 2021
PLOS One
Estrogen and COVID-19 symptoms: Associations in women from the COVID Symptom Study
10th September 2021
The Lancet Infectious Diseases
Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: A prospective, community-based, nested, case-control study
1st September 2021
The Lancet Child & Adolescent Health
Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2
3rd August 2021
The Lancet Digital Health
Early detection of COVID-19 in the UK using self-reported symptoms: A large-scale, prospective, epidemiological surveillance study
29th July 2021
The Lancet Digital Health
Anosmia, ageusia, and other COVID-19-like symptoms in association with a positive SARS-CoV-2 test, across six national digital surveillance platforms: An observational study
22nd July 2021
The Lancet eClinical Medicine
Race, ethnicity, community-level socioeconomic factors, and risk of COVID-19 in the United States and the United Kingdom
16th July 2021
Nature Communications
Association of social distancing and face mask use with risk of COVID-19
18th June 2021
Nature Medicine
Author Correction: Attributes and predictors of long COVID
27th May 2021
The Lancet Infectious Diseases
Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: A prospective observational study
27th April 2021
The Lancet Public Health
Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: An ecological study
12th April 2021
Scientific Reports
Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts
25th March 2021
Science Advances
Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app
19th March 2021
Nature Medicine
Attributes and predictors of long COVID
10th March 2021
Journal of Infection
Optimal symptom combinations to aid COVID-19 case identification: Analysis from a community-based, prospective, observational cohort
12th February 2021
Med
A prediction model to prioritize individuals for a SARS-CoV-2 test built from national symptom surveys
12th February 2021
BJD
Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection
14th January 2021
Frontiers in Medicine
Effects of environmental factors on severity and mortality of COVID-19
10th January 2021
Thorax
Current smoking and COVID-19 risk: Results from a population symptom app in over 2.4 million people
5th January 2021
Thorax
Geo-social gradients in predicted COVID-19 prevalence in Great Britain: Results from 1,960,242 users of the COVID-19 Symptoms Study app
29th December 2020
The Lancet Public Health
Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: A prospective, observational study
3rd December 2020
Twin Research and Human Genetics
Self-reported symptoms of COVID-19, including symptoms most predictive of SARS-CoV-2 infection, are heritable
December 2020
The Lancet
Widespread smell testing for COVID-19 has limited application – Authors' reply
3rd November 2020
The Lancet Healthy Longevity
Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults
November 2020
Journal of Infection
Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England
14th October 2020
Age and Ageing
Probable delirium is a presenting symptom of COVID-19 in frail, older adults: A cohort study of 322 hospitalised and 535 community-based older adults
28th September 2020
The Oncologist
Cancer and risk of COVID-19 through a general community survey
26th August 2020
The Lancet Public Health
Risk of COVID-19 among front-line health-care workers and the general community: A prospective cohort study
31st July 2020
Cancer Epidemiology, Biomarkers & Prevention
The COronavirus Pandemic Epidemiology (COPE) Consortium: A call to action
1st July 2020
The Lancet
Quantifying additional COVID-19 symptoms will save lives
4th June 2020
Nature Medicine
Real-time tracking of self-reported symptoms to predict potential COVID-19
11th May 2020
Science
Rapid implementation of mobile technology for real-time epidemiology of COVID-19
5th May 2020
